Real-life Data on the Effect of Medical Therapy for Amiodarone-induced Thyrotoxicosis on Cardiovascular (CV) Events and Hospitalizations
Authors' conclusion
The first medical therapy of AIT influences the exposure time to thyrotoxicosis and the occurrence of CV events and hospitalizations.
Study context
- Population
- Patients with amiodarone-induced thyrotoxicosis (AIT) at a referral center
- Participants
- 313 patients
- Exposure
- Appropriate vs inappropriate first-line medical therapy for AIT
- Outcome
- CV events and hospitalizations
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Inappropriate therapies
33.2% (CV events); 24.9% (hospitalizations)
Appropriate therapies
4.5% (CV events); 6.5% (hospitalizations)
P < 0.0001 for both
Observational data: associations, not effects.
Further findings
Treatment received
- Appropriate therapies
- 34.5%
- OMT
- 28.1%
- RCT
- 6.4%
- Inappropriate therapies
- 65.5%
Serum thyroid hormone concentrations, first diagnosis to referral
- Reduced with appropriate therapies, unlike inappropriate therapies
- P = 0.018
Duration of exposure to thyrotoxicosis as risk factor
- Arrhythmias, HR (P = .0008)
- 1.004
- Major acute CV events, HR (P = .020)
- 1.004
- Hospitalizations, HR (P < .0001)
- 1.006
- Duration longer with inappropriate therapies
Original publication
Real-life Data on the Effect of Medical Therapy for Amiodarone-induced Thyrotoxicosis on CV Events and Hospitalizations. J Clin Endocrinol Metab. Published 31 December 2022. doi:10.
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