Genetically predicted selenium concentrations and thyroid function: A two‐sample Mendelian randomization study
Authors' conclusion
The present MR study indicated that high Se concentration enable the decreasing of FT4 levels, and the effects of Se concentrations on FT4 remain sex-specific.
Study context
- Population
- Genome-wide association study (GWAS) summary statistics: blood selenium (Se) and toenail Se; thyroid phenotypes from ThyroidOmics consortium (thyroid-stimulating hormone (TSH) n = 54,288; Free thyroxin (FT4) n = 49,269; hypothyroidism n = 53,423; hyperthyroidism n = 51,823)blood Se 5,477 · toenail Se 4,162
- Comparison
- Genetically predicted Se concentrations and thyroid function
- Outcome
- FT4
Methodological detailsinverse-variance weighted method, weighted median and mode-based sensitivity analyses
- Inverse-variance weighted method
- Weighted median and mode-based sensitivity analyses
Main finding
As reported in the abstract
Genetically determined toenail and blood (TAB) Se and FT4, β (95% CI −0.106, −0.028; p = 0.001), inverse-variance weighted (IVW); also in weighted median and weighted-mode analyses
−.067
Further findings
Hypothyroidism
- Suggestive association of higher TAB Se with lower hypothyroidism risk, IVW OR
- 0.847 (95% CI 0.728, 0.985; p = 0.031)
FT4 in women
- TAB Se and FT4 in women, β (95% CI −0.129, −0.024; p = 0.004)
- −.076
TSH and hyperthyroidism
- No significant effect of higher Se on TSH or hyperthyroidism in primary and sensitivity analyses
Original publication
Genetically predicted selenium concentrations and thyroid function: A two‐sample Mendelian randomization study. Clin Endocrinol (Oxf). Published 25 December 2022. doi:10.
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