Low T3 Syndrome on Admission and Response to Nutritional Support in Malnourished Medical Inpatients
Primary result · All-cause mortalityResult — go to the resultAdjusted hazard ratio 1.97 95% CI 1.17–3.31Authors' conclusion
Our secondary analysis of a randomized trial suggests that medical inpatients at nutritional risk with low T3 syndrome have a substantial increase in mortality and may show a more pronounced beneficial response to nutritional support interventions.
Study context
- Population
- Adult medical inpatients at nutritional risk in EFFORT (individualized nutritional support vs usual care), with complete data incl. fT3of 2028 in trial
- Participants
- 801 inpatients
- Comparison
- Low T3 syndrome vs no low T3 syndrome
- Low T3 syndromen = 492
- Primary endpoint
- All-cause mortality
- Follow-up
- 30, 180 days, and 5 years
Methodological detailsrandomized controlled, multicenter, Swiss
- Randomized controlled
- Multicenter
- Swiss
Primary result
As reported in the abstract
30 days
Adjusted hazard ratio
1.97
95% CI 1.17–3.31
P = 0.011
Low T3 syndromevs No low T3 syndrome
aHR 1.97 (95% CI 1.17–3.31); P = 0.011
Further findings
Other adverse clinical outcomes
- Low T3 syndrome associated with other adverse clinical outcomes
Mortality with nutritional support vs usual care, by low T3 syndrome subgroup
- aOR of nutritional support, low T3 syndrome
- 0.82 [95% CI 0.47-1.41]
- aOR of nutritional support, no low T3 syndrome
- 1.47 [95% CI 0.55-3.94]
- Interaction
- P for interaction = 0.401
- Not significant in interaction analysis
Original publication
Low T3 Syndrome on Admission and Response to Nutritional Support in Malnourished Medical Inpatients. J Clin Endocrinol Metab. Published 22 December 2022. doi:10.
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