Higher Peripheral Thyroid Sensitivity Is Linked to a Lower Risk of Heart Failure After Acute Myocardial Infarction
Authors' conclusion
The thyroid hormone peripheral sensitivity of the FT3/FT4 ratio is an independent predictor of HF and mortality after AMI.
Study context
- Population
- Inpatients with acute MI (acute myocardial infarction (AMI)); median age 61.0 years, 68.9% male
- Participants
- 3,648 inpatients
- Exposure
- Highest vs lowest quartile of free triiodothyronine (FT3)/free thyroxine (FT4) ratio
- Outcome
- Heart failure (HF) after AMI during and after hospitalization
Main finding
As reported in the abstract
HF after AMI (fully adjusted model)
Q4 vs Q1Estimate (95% CI)P value
In-hospital HF; risk reduced by 44%
OR 0.56(0.44–0.72)
P < 0.001for trendOut-of-hospital HF; risk reduced by 37%
HR 0.63(0.48–0.84)
P < 0.001for trendObservational data: associations, not effects.
Secondary outcomes
All-cause and CV death after hospitalization
- Risks of all-cause and CV death significantly reduced in Q4 vs Q1
Subgroup analyses
- Consistent with the overall results
Sensitivity analysis in euthyroid sample
- Consistent with the main sample
- 2484 patients
Mediation analysis
- Altered NT-proBNP levels mediated the association between FT3/FT4 ratio and all endpoints
Original publication
Higher Peripheral Thyroid Sensitivity Is Linked to a Lower Risk of Heart Failure After Acute Myocardial Infarction. J Clin Endocrinol Metab. Published 27 April 2023. doi:10.
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