Association of sensitivity to thyroid hormones with all-cause mortality in euthyroid US adults: a nationwide cohort study
Authors' conclusion
Increased risk for all-cause mortality was positively associated with TFQIFT4, suggesting that increased risk for all-cause mortality was associated with decreased central sensitivity to thyroid hormones. Furthermore, the FT3/FT4 ratio showed a U-shaped association with mortality, with an inflection point at 0.5.
Study context
- Population
- Euthyroid US adults, National Health and Nutrition Examination Survey (NHANES) 2007–2012
- Participants
- 6,243 adults
- Exposure
- Quartiles of thyroid hormone sensitivity indices: Q4 vs Q1
- Outcome
- All-cause mortality
Methodological detailsnationwide, NHANES 2007-2012, multivariable Cox proportional hazard regression, restricted cubic spline, subgroup analysis
- Nationwide
- NHANES 2007-2012
- Multivariable Cox proportional hazard regression
- Restricted cubic spline
- Subgroup analysis
Main finding
As reported in the abstract
All-cause mortality by thyroid hormone sensitivity index
Q4 vs Q1Odds ratio (95% CI)P value
FT3/FT4 ratio; lower mortality in Q4
0.70(0.51–0.94)
P < 0.05, allTFQIFT4; 43% higher mortality in Q4
1.43(1.05–1.96)
P < 0.05, allObservational data: associations, not effects.
Original publication
Association of sensitivity to thyroid hormones with all-cause mortality in euthyroid US adults: a nationwide cohort study. Eur Thyroid J. Published 29 January 2024. doi:10.
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