Impaired Thyroid Hormone Sensitivity Increases Risk of Cardiovascular Events in Patients Undergoing Coronary Angiography
Authors' conclusion
Impaired sensitivity to thyroid hormone is associated with higher risks of MACE and cardiovascular death in a euthyroid population undergoing coronary angiography.
Study context
- Population
- Euthyroid participants undergoing coronary angiography, March–November 20131,089 completed follow-up
- Participants
- 1,470 participants
- Exposure
- Higher vs lower levels of thyroid hormone sensitivity indices
- Outcome
- MACE and cardiovascular death
- Follow-up
- Median 111 months
Main finding
As reported in the abstract
MACE
Hazard ratio (95% CI)P value
Higher TFQI
1.41(1.08–1.84)
P = 0.01for trendHigher TT4RI
1.40(1.06–1.84)
P = 0.02for trendHigher TSHI
1.61(1.22–2.13)
P = 0.001for trend- Major adverse cardiovascular events (MACE) cases
- 342
Observational data: associations, not effects.
Further findings
Cardiovascular death
| HR (95% CI) | P value | ||
|---|---|---|---|
| Higher TFQIMultivariable Cox proportional hazard model | 2.21 (1.17–4.17) | P for trend = 0.02 | |
| Higher TSHIMultivariable Cox proportional hazard model | 2.05 (1.08–3.91) | P for trend = 0.03 | |
| 0.20.5125Hazard ratio (log scale) |
- Cardiovascular death — Cardiovascular deaths
- 77
Original publication
Impaired Thyroid Hormone Sensitivity Increases Risk of Cardiovascular Events in Patients Undergoing Coronary Angiography. J Clin Endocrinol Metab. Published 16 December 2023. doi:10.
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