Glucose tolerance and insulin resistance/sensitivity associate with retinal layer characteristics: the LIFE-Adult-Study
Authors' conclusion
An impaired glucose homeostasis associates with a thinning of the optical bands of retinal ONL and photoreceptor MZ. Changes in ONL and MZ thicknesses might predict early metabolic retinal alterations in diabetes.
Study context
- Population
- Healthy eyes of participants of the LIFE-Adult-Study, randomly selected from the population registry of Leipzig, Germany; Spectral domain optical coherence tomography (SD-OCT) thicknesses of ten optical retinal bands
- Participants
- 7,384 healthy eyes
- Exposure
- Normal glucose tolerance vs Prediabetes vs Diabetes
- Outcome
- Association of glucose metabolism markers with SD-OCT retinal band thickness
Methodological detailspopulation-based, multivariable linear regression adjusted for age, sex and refraction
- Population-based
- Multivariable linear regression adjusted for age, sex and refraction
Main finding
As reported in the abstract
Outer nuclear layer (ONL) thickness vs HOMA2-IR, standardised β
−0.096
p<0.001
Myoid zone (MZ) thickness vs HOMA2-IR, β
−0.096
p<0.001
ONL thickness vs eGDR, β
0.090
p<0.001
MZ thickness vs eGDR, β
0.133
p<0.001
Observational data: associations, not effects.
Further findings
- Global associations confirmed in Early Treatment Diabetic Retinopathy Study (ETDRS) subfield-specific analyses and validated in sensitivity analyses
Original publication
Glucose tolerance and insulin resistance/sensitivity associate with retinal layer characteristics: the LIFE-Adult-Study. Diabetologia. Published 2 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →