The number of nephroprotection targets attained is associated with cardiorenal outcomes and mortality in patients with diabetic kidney disease. The chronic kidney disease (CKD)‐REIN cohort study
Main finding · Cardiorenal eventsResult — go to the resultHazard ratio 0.70 95% CI 0.57–0.85Authors' conclusion
These findings suggest that the attainment of a combination of nephroprotection targets is associated with better cardiorenal outcomes and a lower mortality rate in people with diabetic kidney disease.
Study context
- Population
- Patients with diabetes and CKD stages 3–4 (eGFR 15–60 ml/min/1.73 m²), French CKD-REIN cohort; 69% men, mean age 70 ± 10 years, eGFR 33 ± 11 ml/min/1.73 m²
- Participants
- 1,260 patients
- Exposure
- Attainment of two nephroprotection targets vs zero or one target
- Outcome
- Cardiorenal events
- Follow-up
- Median 4.9 years
Methodological detailsadjusted Cox regression
- Adjusted Cox regression
Main finding
As reported in the abstract
Hazard ratio
0.70
95% CI 0.57–0.85
Two targetsvs Zero or one target
HR 0.70 (95% CI 0.57–0.85)
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | |
|---|---|---|
| Incident kidney failure with replacement therapyAdjusted | 0.58 (0.43–0.77) | |
| 4-point MACE (CV death, MI, stroke, hospitalization for HF)Adjusted | 0.75 (0.57–0.99) | |
| All-cause mortalityAdjusted | 0.59 (0.42–0.82) | |
| 0.512Hazard ratio (log scale) |
Subgroup urinary albumin-creatinine ratio ≥300 mg/g: at least two targets vs no targets
- Cardiorenal events, HR (at least two vs zero targets)
- 0.61 (0.39-0.96)
- 4-point MACE, HR
- 0.53 (0.28-0.98)
- All-cause mortality, HR
- 0.35 (0.17-0.70)
Original publication
The number of nephroprotection targets attained is associated with cardiorenal outcomes and mortality in patients with diabetic kidney disease. The CKD‐REIN cohort study. Diabetes Obes Metab. Published 28 February 2024. doi:10.
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