Dysregulated 24 h melatonin secretion associated with intrinsically photosensitive retinal ganglion cell function in diabetic retinopathy: a cross-sectional study
Authors' conclusion
ipRCG dysfunction in diabetic retinopathy is associated with disruptions of the 24 h melatonin rhythm, suggesting circadian dysregulation in diabetic retinopathy.
Study context
- Population
- Participants with T2D, with or without DR, undergoing 24 h blood sampling for melatonin and cortisol
- Participants
- 14 vs 9
- Exposure
- T2D with DR vs T2D without DR
- With DRn = 14
- Without DRn = 9reference
- Outcome
- Intrinsically photosensitive retinal ganglion cell (ipRGC) function (PIPR), 24 h melatonin and sleep variability
Methodological detailscontrolled laboratory conditions
- Controlled laboratory conditions
Main finding
As reported in the abstract
- With DR vs Without DR: P = 0.007
- With DR vs Without DR: P = 0.042
- With DR vs Without DR: P = 0.012
Observational data: associations, not effects.
Further findings
- No detectable dim-light melatonin onset — With DR
- 6 events
24 h cortisol profiles, sleep duration and efficiency
- Similar in both groups
Correlation of post-illumination pupil response (PIPR) with 24 h mean melatonin
- R
- 0.555, p=0.007
Original publication
Dysregulated 24 h melatonin secretion associated with intrinsically photosensitive retinal ganglion cell function in diabetic retinopathy: a cross-sectional study. Diabetologia. Published 27 February 2024. doi:10.
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