Associations of variability in blood glucose and systolic blood pressure with mortality in patients with coronary artery disease: A retrospective cohort study from the MIMIC-IV database
Authors' conclusion
GV and SBPV have additive effects on the risk of mortality in patients with CAD hospitalized in the ICU. Ventricular arrhythmias partially mediate the effects of GV and SBPV on in-hospital mortality.
Study context
- Population
- Patients with coronary artery disease hospitalised in the intensive care unit (ICU), MIMIC-IV database
- Participants
- 4,237 patients
- Exposure
- High vs lower glycemic variability and systolic BP variability
- Outcome
- Mortality (in-hospital and 1-year)
Methodological detailsMIMIC-IV database
- MIMIC-IV database
Main finding
As reported in the abstract
Mortality
Died in hospital
400 patients
Died during 1-year follow-up
967 patients
Observational data: associations, not effects.
Further findings
Mediation of glycemic variability (GV) and systolic blood pressure variability (SBPV) effects on in-hospital mortality by ventricular arrhythmias
%
- Proportion mediated, GV
- 18.0
- Proportion mediated, SBPV
- 6.6
Original publication
Associations of variability in blood glucose and systolic blood pressure with mortality in patients with coronary artery disease: A retrospective cohort study from the MIMIC-IV database. Diabetes Res Clin Pract. Published 24 February 2024. doi:10.
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