MicroRNA ‐mediated Ets1 repression in retinal endothelial cells: A novel anti‐angiogenic mechanism in nonproliferative diabetic retinopathy
Authors' conclusion
The identification of a novel microRNA involved in the anti-angiogenic mechanism in NPDR provides new insights into the molecular underpinnings of endothelial dysfunction in diabetic retinopathy. Our retina-specific circulating microRNA panel has potential utility in risk assessment and early detection of NPDR.
Study context
- Population
- T2D patients with and without nonproliferative diabetic retinopathy (NPDR); plasma and retina samples; single-cell sequencing data from mouse and rat models
- Comparison
- T2D patients with vs without NPDR
- Outcome
- Regulatory mechanisms of angiogenesis in NPDR
Methodological detailsmicroRNA sequencing, integrative single-cell sequencing analysis (mouse and rat models)
- microRNA sequencing
- Integrative single-cell sequencing analysis (mouse and rat models)
Main finding
As reported in the abstract
- A specific set of circulating microRNAs with strong predictive potential for distinguishing NPDR patients
- A novel microRNA targeting Ets1, a key regulator of microvascular angiogenesis, upregulated in plasma of NPDR patients
- Ets1 expression downregulated in diabetic endothelial cells, associated with repression of Angiopoietin-1 and PI3K-Akt signalling pathways, indicating an anti-angiogenic mechanism in NPDR
Observational data: associations, not effects.
Original publication
MicroRNA ‐mediated Ets1 repression in retinal endothelial cells: A novel anti‐angiogenic mechanism in nonproliferative diabetic retinopathy. Diabetes Obes Metab. Published 7 January 2025. doi:10.
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