Diabetes and risk of heart failure in people with and without cardiovascular disease: systematic review and meta-analysis
Authors' conclusion
Peoplewith T2D, compared to those without diabetes, have similar increased risk of HF, regardless of CVD prevalence. Strategiesproven to lower HF risk in T2D individuals should be prioritized for those with and without CVD.
Study context
- Population
- Individuals with and without cardiovascular disease (CVD) in observational cohort studies (PubMed, Scopus, Web of Science to 22nd March 2023)31 T2D and 6 T1D studies
- Comparison
- Diabetes vs no diabetes, in people with and without CVD
- Outcome
- Incident HF
Methodological detailsrandom-effects model, meta-regression
- Random-effects model
- Meta-regression
Pooled result
As reported in the abstract
Incident HF, T2D vs without diabetes, by CVD status
T2D vs Without diabetesRelative risk (95% CI)
With CVD
1.61(1.35–1.92)
Without CVD
1.78(1.60–1.99)
Unspecified CVD prevalence
2.02(1.75–2.33)
- Meta-regression: no significant difference in heart failure (HF) risk in T2D with vs without CVD
- P = 0.232
Original publication
Diabetes and risk of heart failure in people with and without cardiovascular disease: systematic review and meta-analysis. Diabetes Res Clin Pract. Published 15 December 2023. doi:10.
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