Excessive occupational sitting increases risk of cardiovascular events among working individuals with type 1 diabetes in the prospective Finnish Diabetic Nephropathy Study
An erratum to this article was published (Cardiovasc Diabetol, 18 Jan 2025 ↗)
Main finding · Cardiovascular eventsResult — go to the resultHazard ratio 1.55 95% CI 1.10–2.18Authors' conclusion
Excessive occupational sitting is associated with a higher risk of cardiovascular events and all-cause mortality in individuals with type 1 diabetes. This association persists regardless of leisure-time physical activity, after adjusting for independently associated variables identified in our cross-sectional analyses. These findings underscore the need to update physical activity guidelines to better address sedentary behavior and improve outcomes for individuals with type 1 diabetes. Targeting occupational sitting should be considered a key focus for interventions aimed at reducing overall sedentary time.
Study context
- Population
- Working individuals with T1D from the Finnish Diabetic Nephropathy Study; mean age 38.9 ± 10.1 years
- Participants
- 1,704 individuals
- Exposure
- Excessive occupational sitting vs less
- Outcome
- Cardiovascular events
- Follow-up
- Median 12.5 (6.5-16.4) years
Methodological detailsobservational follow-up study
- Observational follow-up study
Main finding
As reported in the abstract
Hazard ratio
1.55
95% CI 1.10–2.18
- Individuals with cardiovascular events
- 163 (9.6%)
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | |
|---|---|---|
| All-cause mortality, current smokers (stratified multivariable analysis) · median follow-up 13.7 (9.4-16.6) yearsExcessive occupational sittingvs Less occupational sitting | 2.06 (1.02–4.20) | |
| 0.20.5125Hazard ratio (log scale) |
- All-cause mortality, current smokers (stratified multivariable analysis) — Deaths (whole cohort)
- 108 (6.3%)
Factors associated with excessive occupational sitting (multivariable logistic regression)
- High occupational category, OR
- 6.53 (4.09-10.40) (95% CI)
- Older age, OR
- 1.02 (1.00-1.03)
- Current smoking, OR
- 0.68 (0.50-0.92)
- Moderate albuminuria, OR
- 0.55 (0.38-0.80)
- High leisure-time physical activity, OR
- 0.52 (0.36-0.74)
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →