Associations Between Sensitivity to Thyroid Hormones and Visceral Adiposity in Euthyroid Adults
Authors' conclusion
Reduced central TH sensitivity was associated with increased visceral adiposity in women but not men. Our findings supplemented the evidence of the importance of TH sensitivity to metabolic disorders, especially among women.
Study context
- Population
- Euthyroid adults (normal thyroid function); 5411 men and 5749 women5,411 men · 5749 women
- Exposure
- Highest vs lowest tertiles of central thyroid hormone (TH) sensitivity indices
- Outcome
- Association of TH sensitivity with obesity assessed by BMI and VAI (high VAI)
Methodological detailsstratified by sex, logistic and linear regressions
- Stratified by sex
- Logistic and linear regressions
Main finding
As reported in the abstract
High VAI in women, highest vs lowest tertile
Odds
1.21
95% CI 1.02–1.44P = 0.03
Highest TFQI tertile (women) vs Lowest tertile (women)
Odds
1.43
95% CI 1.20–1.70P < 0.001
Highest TSH index (TSHI) tertile (women) vs Lowest tertile (women)
Odds
1.47
95% CI 1.23–1.75P < 0.001
Highest thyrotrophic T4 resistance index (TT4RI) tertile (women) vs Lowest tertile (women)
Observational data: associations, not effects.
Further findings
| Outcome | Difference (kg/m²) | P value |
|---|---|---|
| BMI in men, highest vs lowest TT4RI tertile | 1 | P = 0.001 |
- Body mass index (BMI) in men, highest vs lowest TT4RI tertile: higher BMI with highest tertile; adjusted for age, hypertension, hyperlipidemia, diabetes, hyperuricemia, renal function
BMI across other tertiles
- No significant difference in BMI across tertiles of TFQI and TSHI in men, and TFQI, TSHI and TT4RI in women after adjustment
Original publication
Associations Between Sensitivity to Thyroid Hormones and Visceral Adiposity in Euthyroid Adults. J Clin Endocrinol Metab. Published 18 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →