Sex Differences in the Association Between Thyroid Hormone Sensitivity and Cardiovascular-Kidney-Metabolic Syndrome
Authors' conclusion
This study demonstrated that impaired thyroid hormone sensitivity was significantly associated with the early-stage of CKM syndrome, particularly in older men. These findings provide the evidence of the importance of thyroid hormone sensitivity in CKM syndrome, especially in men over the age of 50.
Study context
- Population
- Euthyroid participantseuthyroid
- Participants
- 8,391 participants
- Exposure
- Thyroid hormone sensitivity indices (TFQI, thyroid-stimulating hormone index (TSHI), thyrotrophic thyroxine resistance index (TT4RI), FT3/FT4 ratio) and stage 2 cardiovascular-kidney-metabolic (CKM) syndrome, stratified by sex and age
- Outcome
- Stage 2 of CKM syndrome
Main finding
As reported in the abstract
Stage 2 CKM syndrome by thyroid hormone sensitivity, by sex
- In men, higher TFQI, TSHI and TT4RI significantly associated with increased risk of stage 2 CKM syndrome
- In women, associations weaker but still present, particularly for TSHI
- RCS: CKM risk tended to increase with decreasing thyroid hormone sensitivity in men; associations in women not as significant
- Older men (>50 years) showed a stronger correlation between thyroid hormone sensitivity and CKM syndrome vs women
- Logistic regression and restricted cubic spline analysis
Observational data: associations, not effects.
Original publication
Sex Differences in the Association Between Thyroid Hormone Sensitivity and Cardiovascular-Kidney-Metabolic Syndrome. J Clin Endocrinol Metab. Published 4 February 2025. doi:10.
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