The Free Triiodothyronine/Free Thyroxine Ratio Is Associated with Frailty in Older Adults: A Longitudinal Multisetting Study
Authors' conclusion
The fT3/fT4 ratio value was inversely correlated with frailty degree and mortality risk in a large cohort of older individuals, including centenarians, regardless of their sex and clinical condition.
Study context
- Population
- Older individuals (aged 86.4 ± 8.9 years; 55.1% females): acutely ill hospitalized patients, nursing-home (NH) residents and home-dwelling centenarians
- Participants
- 615 individuals3 cohorts
- Comparison
- Association of free triiodothyronine (fT3)/free thyroxine (fT4) ratio with Frailty Index
- GAUn = 298
- NHn = 250
- Centenarians (CENT)n = 67
- Primary endpoint
- Relationship between fT3/fT4 ratio and degree of frailty (30-item Frailty Index)
Methodological detailsmultisetting, longitudinal, patient-level data
- Multisetting
- Longitudinal
- Patient-level data
Primary result
As reported in the abstract
fT3/fT4 ratio vs Frailty Index
Inverse correlation, fT3/fT4 ratio vs Frailty Index (FI)
−0.17
ρs; CI −0.092 to 0.252p < 0.001
Logistic multivariate analysis, adjusted for age, sex, cohorts: OR
0.64
CI 0.47–0.87; β = −0.44p < 0.001
Further findings
Mortality risk with rising fT3/fT4 ratio
- OR
- 0.60 (CI 0.44-0.80; β = −0.51; p < 0.001)
Original publication
The Free Triiodothyronine/Free Thyroxine Ratio Is Associated with Frailty in Older Adults: A Longitudinal Multisetting Study. Thyroid. Published 14 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →