Variation in the reference range limits of thyroid function tests and association with the prevalence of levothyroxine treatment
Authors' conclusion
We conclude that minor changes in the reference range limits for serum TSH and FT4 are associated with levothyroxine treatment.
Study context
- Population
- UK National Health Service (NHS) laboratories and corresponding health areas, 2014
- Comparison
- TSH and free thyroxine (FT4) reference interval limits reported by UK NHS laboratories vs prevalence of LT4 treatment
- Outcome
- Prevalence of LT4 treatment
- Follow-up
- 2014
Main finding
As reported in the abstract
Prevalent LT4 treatment by reference interval limits
Upper limit of serum TSH: significantly, linearly, independently and negatively associated with prevalent LT4 treatment
−0.54%
95% CI −0.68% to −0.40%
Original publication
Variation in the reference range limits of thyroid function tests and association with the prevalence of levothyroxine treatment. Eur J Endocrinol. Published 8 February 2023. doi:10.
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