Investigating factors associated with thyroid hormone measurements during pregnancy
Authors' conclusion
Gestational thyroid hormone concentrations appear to be influenced by HCG levels. As with LC-MS/MS use, immunoassay measurements may vary with albumin and TBG concentrations. These findings underscore the need to consider such fluctuations when interpreting thyroid function tests in pregnant women.
Study context
- Population
- Pregnant women; Free thyroxine (FT4), free triiodothyronine (FT3) and TSH measured with human chorionic gonadotropin (HCG), albumin and thyroxine-binding globulin (TBG)897 serum samples
- Participants
- 604 women
- Exposure
- Chemiluminescent immunoassay (CLIA) vs electrochemiluminescence immunoassay (ECLIA) immunoassays
- LC-MS/MSn = 176
- Outcome
- TSH <0.01 mIU/L
- Follow-up
- Throughout pregnancy
Methodological detailsmethod comparison (CLIA, ECLIA, LC-MS/MS), multivariable regression analysis
- Method comparison (CLIA, ECLIA, LC-MS/MS)
- Multivariable regression analysis
Main finding
As reported in the abstract
Observational data: associations, not effects.
Original publication
Investigating factors associated with thyroid hormone measurements during pregnancy. Eur Thyroid J. Published 29 August 2025. doi:10.
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