Association of B7H3 and B7H4 gene polymorphisms and protein expression with the development and prognosis of autoimmune thyroid diseases
Authors' conclusion
B7H3 and B7H4 are associated with AITD susceptibility and prognosis.
Study context
- Population
- Patients with autoimmune thyroid diseases (Graves' disease (GD), Hashimoto's disease (HD)) and healthy volunteers
- Participants
- 187 / 217 / 110
- Comparison
- GD and HD patients vs healthy volunteers
- GDn = 187
- HDn = 217
- Healthy volunteersn = 110reference
- Outcome
- B7H3/B7H4 SNPs and B7-H3/B7-H4 expression in AITD
Methodological detailsMembrane B7-H3/B7-H4 by flow cytometry; soluble forms by ELISA; SNP genotyping by PCR-RFLP
- Membrane B7-H3/B7-H4 by flow cytometry; soluble forms by ELISA; SNP genotyping by PCR-RFLP
Main finding
As reported in the abstract
- B7H3 rs3816661 CC genotype more frequent in severe HD
- G carriers of B7H4 rs10754339 A/G and rs13505 T/G more frequent in AITD
- A carriers of B7H4 rs10158166 A/G and C carriers of B7H4 rs3806373 C/T more frequent in intractable GD
- B7-H3+ monocytes higher in B7H3 rs3816661 CC genotype than other genotypes, and lower in GD and HD than healthy controls
- Soluble B7-H4 lower in B7H4 rs13505 TG than TT genotype, and higher in AITD than healthy controls
Observational data: associations, not effects.
Original publication
Association of B7H3 and B7H4 gene polymorphisms and protein expression with the development and prognosis of autoimmune thyroid diseases. Clin Endocrinol (Oxf). Published 26 April 2023. doi:10.
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