Association Between Eight Autoimmune Diseases and Thyroid Cancer: A Nationwide Cohort Study
Authors' conclusion
Specific ADs-especially for thyroid-specific AD, vitiligo, IBD, and RA-were associated with increased risk for thyroid cancer.
Study context
- Population
- Participants of the National Health Insurance Service-National Sample Cohort with eight autoimmune diseases (ADs) vs matched controls without ADsmatched cohort
- Exposure
- Eight autoimmune diseases vs no AD
- Outcome
- Incident thyroid cancer
- Follow-up
- Average 9.49 years
Methodological detailsnationwide, matched cohort, Cox proportional hazard model, adjusted HR
- Nationwide
- Matched cohort
- Cox proportional hazard model, adjusted HR
Main finding
As reported in the abstract
Control
138
events
Each group vs controlAdjusted hazard ratio (CI)
Hashimoto's thyroiditis
2.10(1.57–2.81)
Graves' disease
2.67(1.99–3.62)
IBD
2.06(1.50–2.83)
Vitiligo
1.71(1.13–2.59)
RA
1.76(1.07–2.90)
Total of 8 ADs
1.97(1.60–2.42)
- Thyroid cancer cases in group with 8 ADs
- 268
Observational data: associations, not effects.
Further findings
| Outcome | aHR (CI) | |
|---|---|---|
| Incident thyroid cancer by AD typeThyroid-specific ADsvs ControlStrongest association | 2.37 (1.85–3.03) | |
| Incident thyroid cancer by AD typeLocal ADsvs Control | 1.83 (1.41–2.38) | |
| Incident thyroid cancer by AD typeSystemic ADsvs Control | 1.77 (1.14–2.74) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Original publication
Association Between Eight Autoimmune Diseases and Thyroid Cancer: A Nationwide Cohort Study. Thyroid. Published 27 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →