Epigenome-wide Association Study Shows Differential DNA Methylation of MDC1, KLF9, and CUTA in Autoimmune Thyroid Disease
Authors' conclusion
Our study reveals differences in DNAm between GD and HD, which may help explain why some people develop GD and others HD and provide a link to environmental risk factors. Additional research is needed to advance understanding of the role of DNAm in AITD and investigate its prognostic and therapeutic potential.
Study context
- Population
- Patients with autoimmune thyroid disease: Australian discovery cohort (32 Graves disease (GD), 30 Hashimoto disease (HD)) and Danish replication cohort (32 GD, 32 HD); whole-blood DNA methylation (Infinium MethylationEPIC array)discovery and replication cohorts
- Comparison
- GD vs HD
- Outcome
- Differentially methylated positions (DMPs) and regions (DMRs) comparing GD to HD
Methodological detailsdiscovery and replication cohorts, meta-analysis
- Discovery and replication cohorts
- Meta-analysis
Pooled result
As reported in the abstract
DMPs and DMRs between GD and HD
Epigenome-wide significant (P < 9E-8) and replicated (P < .05) differentially methylated positions (DMPs): cg06315208 within MDC1 and cg00049440 within KLF9
2
Identified and replicated DMR within CUTA (6p21.32)
5 CpGs
Further pooled results
- DMPs in meta-analysis
- 64
- Differentially methylated regions (DMRs) in meta-analysis
- 137
Original publication
Epigenome-wide Association Study Shows Differential DNA Methylation of MDC1, KLF9, and CUTA in Autoimmune Thyroid Disease. J Clin Endocrinol Metab. Published 14 November 2023. doi:10.
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