Hypothyroid women have persistently higher oxidative stress compared to healthy controls
Authors' conclusion
In hypothyroid women, no significant effect of levothyroxine treatment on the oxidative stress biomarkers 8-oxoGuo and 8-oxodG could be demonstrated. However, the excretion of these biomarkers was significantly higher than in healthy controls.
Study context
- Population
- Danish women with newly diagnosed hypothyroidism
- Participants
- 45 / 45 / 18
- Exposure
- Hypothyroid women before vs after LT4-restored euthyroidism; euthyroid patients vs healthy controls
- Baselinen = 45reference
- Euthyroidismn = 45
- Controlsn = 18
- Outcome
- Urinary excretion of 8-oxoGuo (RNA oxidation) and 8-oxodG (DNA oxidation)
Methodological detailsbefore–after comparison, healthy control comparison
- Before–after comparison
- Healthy control comparison
Main finding
As reported in the abstract
Urinary 8-oxoGuo (RNA oxidation), geometric mean · baseline vs euthyroidism
P = 0.39
- Relative mean difference, 8-oxoGuo
- 0.97 (95% CI: 0.91-1.04)
Observational data: associations, not effects.
Further findings
Geometric mean, nmol/mmol creatinine
| Outcome | Baseline | Euthyroidism | Controls | P value |
|---|---|---|---|---|
| Urinary 8-oxodG (DNA oxidation), geometric mean · baseline vs euthyroidismNo significant change | 1.28 (95% CI 1.14–1.44) | 1.32 (95% CI 1.18–1.48) | — not stated in the abstract | P = 0.47 |
| 8-oxoGuo, euthyroid patients vs healthy controls · euthyroidismSignificantly higher in euthyroid patients | — not stated in the abstract | — not stated in the abstract | 1.23 (95% CI 1.07–1.42) | P < 0.001 |
| 8-oxodG, euthyroid patients vs healthy controls · euthyroidismSignificantly higher in euthyroid patients | — not stated in the abstract | — not stated in the abstract | 1.04 (95% CI 0.88–1.23) | P = 0.03 |
— not stated in the abstract
- Urinary 8-oxodG (DNA oxidation), geometric mean — Relative mean difference, 8-oxodG
- 0.97 (95% CI: 0.88-1.06)
Associations at baseline (multiple linear regression)
- FT4 positively associated with 8-oxoGuo
- P < 0.001
- FT4 positively associated with 8-oxodG
- P = 0.04
- 8-oxoGuo positively associated with age
- P = 0.04
- 8-oxoGuo negatively associated with TSH
- P = 0.02
Original publication
Hypothyroid women have persistently higher oxidative stress compared to healthy controls. Eur Thyroid J. Published 3 November 2023. doi:10.
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