Metabolomic profile of patients on levothyroxine treatment for hypothyroidism
Authors' conclusion
A metabolomic analysis of patients with hypothyroidism revealed significant changes in several metabolites and lipids after treatment. This study showed the value of the metabolomics technique in providing a complementary understanding of the pathophysiology of hypothyroidism and as a crucial tool for examining the molecular impact of levothyroxine treatment on hypothyroidism. It was an important tool for investigating the therapeutic effects of levothyroxine on hypothyroidism at the molecular level.
Study context
- Population
- Patients diagnosed with overt hypothyroidism
- Participants
- 18 patients
- Comparison
- After vs before LT4 treatment
- Outcome
- Plasma metabolomic profile
Methodological detailsbefore-and-after, high-resolution mass spectrometry-based metabolomics
- Before-and-after
- High-resolution mass spectrometry-based metabolomics
Main finding
As reported in the abstract
- Significant decrease in ceramide, phosphatidylcholine, TG, acylcarnitine and peptides after LT4 treatment
- Considerable rise in glycocholic acid following therapy
Original publication
Metabolomic profile of patients on levothyroxine treatment for hypothyroidism. Eur Thyroid J. Published 27 July 2023. doi:10.
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