Quality of life in patients with overt hypothyroidism: a systematic review
Authors' conclusion
Based on this systematic review and meta-analysis, despite methodological concerns in the available literature, QoL in patients with hypothyroidism is impaired. Future studies should address potential residual bias displayed and explore the impact of disease etiology, duration, and timing of diagnosis in relation to comorbidity, to reveal groups of patients susceptible to inadequate treatment response and guide our way to improve QoL in hypothyroidism.
Study context
- Population
- Adults with Hashimoto's thyroiditis (HT) or congenital hypothyroidism (CH), treated with levothyroxine (LT4) for 6 months17 studies
- Outcome
- QoL in long-term treated hypothyroidism (mental well-being, physical well-being, social role)
Methodological detailsrandom effects model, Newcastle-Ottawa Scale quality assessment, 797 articles screened; 52 full-text assessed; 17 included, Two meta-analyses, random effects model
- Random effects model
- Newcastle-Ottawa Scale quality assessment
- 797 articles screened; 52 full-text assessed; 17 included
- Two meta-analyses, random effects model
Pooled result
As reported in the abstract
QoL
- Studies including patients with HT
- 14
- Studies evaluating quality of life (QoL) in CH
- 3
- Studies with impaired mental and physical well-being
- 10
- Studies detecting social role impairments
- 7
- Studies with flawed design
- 13
Original publication
Quality of life in patients with overt hypothyroidism: a systematic review. Eur J Endocrinol. Published 5 September 2025. doi:10.
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