Hashimoto's Thyroiditis Beyond Thyroid Hormones: A Systematic Review of Autoimmunity, Inflammation, and Multidimensional Burden
Authors' conclusion
There is evidence that HT exerts a multidimensional impact beyond endocrine dysfunction, with chronic autoimmunity and low-grade inflammation contributing to impaired QoL.
Study context
- Population
- Adults with Hashimoto's thyroiditis; observational, interventional and longitudinal studies reporting quality of life (QoL) outcomes and immune/inflammatory markers (MEDLINE, Scopus, Web of Science)
- Comparison
- Hashimoto's thyroiditis (HT) patients vs controls
- Outcome
- QoL and thyroid autoimmunity
Methodological detailsPRISMA
- PRISMA
Pooled result
As reported in the abstract
- HT patients consistently reported lower QoL vs controls, particularly cognitive, affective and vitality domains
- Elevated anti-TPO and anti-Tg antibodies negatively correlated with QoL
- Thyroid-stimulating hormone (TSH) and thyroid hormone levels showed no consistent association with QoL
Further pooled results
Interventional studies
- Total thyroidectomy or therapies associated with reduced antibody titers accompanied by improvements in fatigue and QoL
- Some studies did not confirm a direct association between antibody levels and symptom severity, likely reflecting methodological variability and heterogeneous QoL tools
Original publication
Hashimoto's Thyroiditis Beyond Thyroid Hormones: A Systematic Review of Autoimmunity, Inflammation, and Multidimensional Burden. Clin Endocrinol (Oxf). Published 2 March 2026. doi:10.
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