Preconception Thyrotropin Levels and Thyroid Function at Early Gestation in Women With Hashimoto Thyroiditis
Authors' conclusion
The preconception TSH cutoffs that guaranteed a first-trimester TSH less than 2.5 mU/L in hypothyroid- and euthyroid-HT women were, respectively, almost 50% (1.24 mU/L) and 30% (1.73 mU/L) lower than this gestational target, and 1.74 mU/L and 2.07 mU/L in hypothyroid- and euthyroid-HT women, respectively, for a gestational target of 4.0 mU/L.
Study context
- Population
- Pregnant women with Hashimoto thyroiditis and preconception TSH consistently ≤2.5 mIU/L, followed from preconception to term
- Participants
- 260 women
- Exposure
- Preconception TSH cutoffs in Hashimoto thyroiditis (HT) women on levothyroxine (LT4) vs euthyroid without LT4
- Hypo-HTn = 122
- Eu-HTn = 138
- Outcome
- Prevalence of first-trimester thyroid insufficiency (TSH >2.5 mIU/L [DC 1] and >4.0 mIU/L [DC 2]) and ROC-based T0-TSH cutoffs predicting it
- Follow-up
- First trimester
Methodological detailsROC analysis
- ROC analysis
Main finding
As reported in the abstract
First-trimester TSH >4.0 mIU/L (DC 2)
| Group | Value | T0-TSH cutoff DC 1 | T0-TSH cutoff DC 2 | OR above cutoff DC 1 (95% CI) | OR above cutoff DC 2 (95% CI) |
|---|---|---|---|---|---|
| Hypo-HT | 19.7% | 1.24 mIU/L | 1.74 mIU/L | 15.92 [5.06-50.15] | 16.68 [5.13-54.24] |
| Eu-HT | 10.1% | 1.73 mIU/L | 2.07 mIU/L | 16.14 [6.47-40.30] | 17.36 [4.30-70.08] |
Value
Hypo-HT19.7%
Eu-HT10.1%
T0-TSH cutoff DC 1
Hypo-HT1.24 mIU/L
Eu-HT1.73 mIU/L
T0-TSH cutoff DC 2
Hypo-HT1.74 mIU/L
Eu-HT2.07 mIU/L
OR above cutoff DC 1 (95% CI)
Hypo-HT15.92 [5.06-50.15]
Eu-HT16.14 [6.47-40.30]
OR above cutoff DC 2 (95% CI)
Hypo-HT16.68 [5.13-54.24]
Eu-HT17.36 [4.30-70.08]
- Hypo-HT vs Eu-HT: P = 0.038 — TSH >4.0 mIU/L
- First-trimester TSH >2.5 mIU/L (DC 1) in both Hypo-HT and Eu-HT
- ≈30%
Observational data: associations, not effects.
Original publication
Preconception Thyrotropin Levels and Thyroid Function at Early Gestation in Women With Hashimoto Thyroiditis. J Clin Endocrinol Metab. Published 9 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →