Dyslipidemia Is a Risk Factor for Hypothyroidism in Women: A Longitudinal Cohort Study from South Korea
Authors' conclusion
In Korean adults, dyslipidemia was associated with development of hypothyroidism in women.
Study context
- Population
- South Korean adults who underwent medical examination and ≥4 biochemical assessments of thyroid function
- Participants
- 1,665 adults
- Exposure
- Baseline dyslipidemia vs no dyslipidemia
- Outcome
- Hypothyroidism (TSH >4.2 mU/L)
- Follow-up
- Median 61.0 months
Methodological detailslongitudinal cohort, multivariate Cox proportional hazards regression
- Longitudinal cohort
- Multivariate Cox proportional hazards regression
Main finding
As reported in the abstract
Hypothyroidism
Dyslipidemia vs No dyslipidemiaEstimate (CI)P value
Women
aHR (women) 2.05(1.31–3.19)
P = 0.002Men
aHR (men) 1.00(0.77–1.30)
P = 0.991- Developed hypothyroidism (whole cohort)
- 24.3% (404/1665)
Observational data: associations, not effects.
Secondary outcomes
Severe subclinical hypothyroidism (SCH) or overt hypothyroidism (OH) in women
- aHR for baseline dyslipidemia, women
- 5.33 (1.41-20.12), p = 0.014
- Multivariate analysis
Hypothyroidism in women by age subgroup
- Age <40 years, aHR
- 2.90 (1.34-6.26, p = 0.007)
- Age ≥40 years, aHR
- 1.85 (1.08-3.14, p = 0.023)
Hypothyroidism in women by body-mass index (BMI) subgroup
- BMI <23 kg/m², aHR
- 1.68 (0.82-3.43, p = 0.151)
- BMI 23-25 kg/m², aHR
- 2.17 (0.93-5.07, p = 0.071)
- BMI ≥25 kg/m², aHR
- 2.82 (1.16-6.86, p = 0.022)
Spontaneous TSH normalization among those with hypothyroidism (excluding first abnormal TSH at last follow-up)
- Spontaneous TSH normalization
- 44.5% (126/283)
Original publication
Dyslipidemia Is a Risk Factor for Hypothyroidism in Women: A Longitudinal Cohort Study from South Korea. Thyroid. Published 4 January 2023. doi:10.
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