The Role of the Parametric Thyroid Feedback Quantile Index in Cardiovascular Risk Evaluation Among Euthyroid Koreans
Authors' conclusion
The PTFQI inversely correlated with cardiovascular risk among euthyroid Koreans, indicating that reduced central sensitivity to thyroid hormone is associated with lower cardiovascular risk. These results underscore the importance of considering population-specific thyroid function parameters in cardiovascular risk assessment.
Study context
- Population
- Euthyroid Korean adults aged 18 to 80 years without previously diagnosed CVD or thyroid disease, 2013–2015 Korea National Health and Nutrition Examination Survey
- Participants
- 5,160 euthyroid adults
- Exposure
- PTFQI quartiles
- Outcome
- Cardiovascular risk by PREVENT and pooled cohort equations scores
Methodological detailsnationally representative survey (KNHANES 2013–2015)
- Nationally representative survey (KNHANES 2013–2015)
Main finding
As reported in the abstract
Cardiovascular risk per higher PTFQI quartile
- CVD, aOR
- −0.55 (95% CI −.92 to −.18)
- Atherosclerotic CVD, aOR
- −0.31 (95% CI −.53 to −.08)
- HF, aOR
- −0.26 (95% CI −.47 to −.05)
- Coronary heart disease, aOR
- −0.15 (95% CI −.28 to −.02)
- Ischemic stroke, aOR
- −0.18 (95% CI −.30 to −.06)
Observational data: associations, not effects.
Further findings
Agreement of risk scores
- Pooled cohort equations score strongly correlated with PREVENT score
Original publication
The Role of the Parametric Thyroid Feedback Quantile Index in Cardiovascular Risk Evaluation Among Euthyroid Koreans. J Clin Endocrinol Metab. Published 22 January 2025. doi:10.
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