Thyroid disease

The Impact of Physical Activity on Thyroid Health: Insights From Representative Data in Korea

J Clin Endocrinol MetabPublished Retrospective cohort study

Authors' conclusion

The present study found an association between thyroid function and moderate PA. Therefore, moderate-intensity PA should be recommended to improve thyroid function.

Study context

Population
Participants of the Korean National Health and Nutrition Examination Survey 2013–2015, excluding abnormal thyroid function test, restricted activity or previous thyroid disease
Participants
5,372 participants
Exposure
High vs moderate vs low physical activity
Outcome
Thyroid function (free T4, TSH) and TPOAb
Methodological detailsnationally representative data
  • Nationally representative data

Main finding

As reported in the abstract

  • Free T4 was lowest in the low physical activity (PA) group; TSH not significantly different among groups
  • Thyroid peroxidase antibodies (TPOAb) titers increased in the order moderate PA, low PA, high PA
  • After adjustment, moderate PA was associated with a high T4 level and a significant decrease in TSH and TPOAb
  • No significant changes in free T4, TSH or TPOAb titer with high PA
  • Adjusted for confounding factors

Observational data: associations, not effects.

Further findings

Subanalysis: females

Females with moderate PA showed a significant decrease in TSH and TPOAb

Insulin sensitivity

Insulin sensitivity increased with moderate PA in both males and females

Subgroup: obese participants

TSH negatively correlated with PA; free T4 decreased with low PA

Sensitivity to thyroid hormone

Sensitivity to thyroid hormone did not differ

Original publication

The Impact of Physical Activity on Thyroid Health: Insights From Representative Data in Korea. J Clin Endocrinol Metab. Published 15 April 2024. doi:10.1210/clinem/dgae178

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