Incidence of hypothyroidism in girls with Turner syndrome in Korea on the basis of real-world evidence from the Korean National Health Insurance Service database
Authors' conclusion
Regular thyroid function testing and antibody screening should be initiated early in life to facilitate the early detection of hypothyroidism in patients with Turner syndrome.
Study context
- Population
- Patients with TS and general population (females) under 65 years of age, South Korea, claims data 2007–2019; those with conditions requiring thyroid hormone replacement excluded
- Participants
- 2,973 vs 21,239,127
- Exposure
- TS vs general population
- Turner syndromen = 2,973
- General populationn = 21,239,127reference
- Outcome
- Incidence of hypothyroidism (thyroid hormone analog prescription ≥180 days with hypothyroidism diagnosis code)
- Follow-up
- 10 years
Methodological detailspopulation-based, claims data (National Health Insurance Service database), 10-year follow-up
- Population-based
- Claims data (National Health Insurance Service database)
- 10-year follow-up
Main finding
As reported in the abstract
Hypothyroidism developed
- Risk of hypothyroidism in TS vs general population before 10 years of age
- ≈45 times greater
Observational data: associations, not effects.
Further findings
Incidence rate per 10 000 person-years, age 0-9 years
Incidence rate per 10 000 person-years, age 10-19 years
Incidence rate per 10 000 person-years, age 20-29 years
Incidence rate per 10 000 person-years, age 30-65 years
Original publication
Incidence of hypothyroidism in girls with Turner syndrome in Korea on the basis of real-world evidence from the Korean National Health Insurance Service database. Eur J Endocrinol. Published 6 August 2025. doi:10.
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