Assessment of Neurodevelopment and Growth in Congenital Hypothyroidism: Serial 6-Year Follow-up Study of 408 Patients
Main finding · Suspected neurodevelopmental disordersResult — go to the resultPropensity score-weighted OR 4.52 95% CI 2.91–7.02Authors' conclusion
The CH group had worse neurodevelopmental outcomes and reduced height-for-age z-score. Outcomes were worse when onset of treatment was increasingly delayed.
Study context
- Population
- Children in a Korean nationwide database, Korean Ages & Stages Questionnaires (K-ASQ) administered annually from 9 to 72 months of age
- Participants
- 919,707 children
- Exposure
- Congenital hypothyroidism vs controls
- Congenital hypothyroidism (CH)n = 408
- Outcome
- Suspected neurodevelopmental disorder measured by the Korean Ages & Stages Questionnaires (K-ASQ)
- Follow-up
- Annually from 9 to 72 months of age
Methodological detailsclaims-based, 1:10 random matching of cases and controls, inverse probability of treatment weighting, generalized estimating equation models, subgroup analysis by age of treatment initiation
- Claims-based
- 1:10 random matching of cases and controls
- Inverse probability of treatment weighting
- Generalized estimating equation models
- Subgroup analysis by age of treatment initiation
Main finding
Suspected neurodevelopmental disorders
Propensity score-weighted OR
4.52
95% CI 2.91–7.02
CHvs Control
propensity score-weighted OR 4.52 (95% CI 2.91–7.02)
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
Prevalence of CH
- Prevalence of CH
- 0.05% (n = 408)
Low height-for-age and elevated BMI-for-age z-score
- Higher risk of low height-for-age z-score with CH, but not of elevated BMI-for-age z-score
Neurodevelopment by age of treatment initiation (subgroup)
- Delayed medication for CH correlated with worse neurodevelopmental outcomes
Original publication
Assessment of Neurodevelopment and Growth in Congenital Hypothyroidism: Serial 6-Year Follow-up Study of 408 Patients. J Clin Endocrinol Metab. Published 19 June 2023. doi:10.
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