Effects of 2-Year Physical Activity and Dietary Intervention on Adrenarchal and Pubertal Development: The PANIC Study
Authors' conclusion
A combined physical activity and dietary intervention attenuates the increase of serum androgen concentrations and sexual maturation in a general population of prepubertal and mostly normal-weight children, independently of changes in body size and composition.
Study context
- Population
- Prepubertal, mostly normal-weight children aged 6–9 years from a general populationintervention 119 girls, 132 boys
- Participants
- 421 participants
- Comparison
- Lifestyle intervention vs control
- Outcome
- Serum DHEA, DHEAS, androstenedione (A4) and testosterone concentrations, and clinical adrenarchal and pubertal signs
- Follow-up
- 2 years
Methodological details2-year, physical activity and dietary intervention
- 2-year
- Physical activity and dietary intervention
Main finding
As reported in the abstract
- Boys: intervention attenuated increase of dehydroepiandrosterone (DHEA)
- P = .032
- Boys: intervention attenuated increase of dehydroepiandrosterone sulfate (DHEAS)
- P = .001
- Boys: intervention attenuated increase of A4
- P = .003
- Boys: intervention attenuated increase of testosterone
- P = .007
- Boys: intervention delayed pubarche
- P = .038
- Girls: intervention attenuated increase of DHEA
- P = .013
- Girls: intervention attenuated increase of DHEAS
- P = .003
Further findings
Baseline characteristics
- No differences between groups in body size and composition, clinical signs of androgen action and serum androgens at baseline
Original publication
Effects of 2-Year Physical Activity and Dietary Intervention on Adrenarchal and Pubertal Development: The PANIC Study. J Clin Endocrinol Metab. Published 17 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →