Transitional Neonatal Hypoglycemia and Adverse Neurodevelopment in Midchildhood
Authors' conclusion
Neonatal hypoglycemia with blood glucose levels of 30 mg/dL or below was associated with an increased risk for suboptimal neurodevelopmental outcomes in midchildhood. These findings imply that treatment strategies should aim to prevent episodes of hypoglycemia at these severely low levels.
Study context
- Population
- Children born 2010–2015 with neonatal blood glucose screening data, randomly selected, single-center tertiary hospital in Germany; children with persistent hypoglycemia diseases or other risk factors for adverse neurodevelopment excluded; tested at ages 7 to 11 yearsmean age 9.1 years
- Participants
- 140 children
- Exposure
- Severe neonatal hypoglycemia vs all blood glucose >30 mg/dL
- Outcome
- Cognitive function measured by full-scale IQ test
- Follow-up
- Ages 7 to 11 years
Methodological detailsretrospectively recruited cohort, single-center, frequency matching for sex, birth weight, gestational age, socioeconomic status and primary risk factors for neonatal hypoglycemia, Testing March 2022–February 2023; data analyzed February–March 2023
- Retrospectively recruited cohort
- Single-center
- Frequency matching for sex, birth weight, gestational age, socioeconomic status and primary risk factors for neonatal hypoglycemia
- Testing March 2022–February 2023; data analyzed February–March 2023
Main finding
Full-scale IQ
Difference
4.8 points
By group
Severe neonatal hypoglycemia
107.0
mean · 95% CI 104.0–109.9
Controls
111.8
mean · 95% CI 108.8–114.8
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | OR (95% CI) | |
|---|---|---|
| Abnormal fine motor function · ages 7 to 11 years | 4.9 (1.5–15.5) | |
| Abnormal visual-motor integration · ages 7 to 11 years | 5.3 (2.1–13.3) | |
| 0.050.21520Odds ratio (log scale) |
Parent-reported T scores for attention problems and ADHD symptoms · ages 7 to 11 years
- Significantly higher T scores for attention problems were reported by parents
- Significantly higher T scores for attention-deficit/hyperactivity disorder symptoms were reported by parents
Original publication
Transitional Neonatal Hypoglycemia and Adverse Neurodevelopment in Midchildhood. JAMA Netw Open. Published 4 March 2024. doi:10.
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