Correct neonatal free thyroxine reference intervals are crucial to detect central congenital hypothyroidism
Authors' conclusion
This study highlights the critical need for age- and assay-specific RIs for plasma fT4 to accurately diagnose central CH in the neonatal period.
Study context
- Population
- Children born 1 March 2018–1 April 2021 in the Netherlands with an abnormal newborn screening (NBS) result suggesting central congenital hypothyroidism (CH), classified as false positive on neonatal confirmatory fT4 ≤ 3 pmol/L above the assay-specific lower limit of the adult reference intervals (RI)4 consented
- Participants
- 6 children
- Outcome
- New diagnosis of central CH on re-evaluation of thyroid function
Methodological detailsnational screening registry (NEORAH)
- National screening registry (NEORAH)
Main finding
As reported in the abstract
New diagnosis of central CH on re-evaluation
Participants with a new diagnosis of central CH
2 of 4
Of these, cases of multiple pituitary hormone deficiencies (MPHD)
1
Observational data: associations, not effects.
Original publication
Correct neonatal free thyroxine reference intervals are crucial to detect central congenital hypothyroidism. Eur J Endocrinol. Published 29 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →