Clinical and Demographic Factors Associated with a Delayed Thyroid-Stimulating Hormone Rise in Infants with Congenital Hypothyroidism: A Retrospective Review of a 10-Year Cohort in Indiana
Authors' conclusion
Our study confirms that prematurity is a significant contributing factor for having a delayed diagnosis of CH. In contrast, other demographic factors such as race, sex, ethnicity, and maternal age do not appear to be associated with a delayed diagnosis. Other post-natal factors that may be associated with an increased risk of a delayed rise in TSH in infants with CH require further exploration.
Study context
- Population
- Infants with congenital hypothyroidism (CH) born in Indiana, diagnosed 2012–2022
- Exposure
- Delayed thyroid-stimulating hormone (TSH) rise vs early detection in infants with CH
- Delayed TSH risen = 73
- Outcome
- Prevalence of a delayed TSH rise in infants with CH
Main finding
As reported in the abstract
Prevalence of delayed TSH rise among infants with CH
Infants meeting criteria for a delayed diagnosis
73
Prevalence of delayed TSH rise
16%
Observational data: associations, not effects.
Further findings
Factors associated with delayed TSH rise
- Lower gestational age and birth weight Z scores associated with higher odds of a delayed TSH rise
- each p ≤ 0.001
- Lower TSH values associated with a delayed diagnosis
- P = 0.010
Original publication
Clinical and Demographic Factors Associated with a Delayed Thyroid-Stimulating Hormone Rise in Infants with Congenital Hypothyroidism: A Retrospective Review of a 10-Year Cohort in Indiana. Horm Res Paediatr. Published 24 January 2025. doi:10.
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