Growth and Recombinant Human Growth Hormone Use in Children with Congenital Chronic Kidney Disease: A Multicentric Contemporary Study
Authors' conclusion
About half of CKD patients received rhGH treatment, resulting in significant height gain. Untreated patients were not adversely affected in terms of height. These data highlight the importance of careful monitoring of growth and rhGH treatment if needed in patients with CKD. </p>.
Study context
- Population
- Children with congenital CKD who underwent kidney transplantation between 2015 and 2020 at age 3–18 years, three pediatric nephrology departments
- Participants
- 87 children
- Exposure
- Recombinant human growth hormone (rhGH)-treated vs rhGH-untreated
- rhGH-treatedn = 42
- rhGH-untreatedn = 45reference
- Outcome
- Height gain with rhGH
- Follow-up
- 1.7 years
Methodological detailsmulticentre, Data collected at CKD diagnosis, rhGH initiation, dialysis initiation and transplantation
- Multicentre
- Data collected at CKD diagnosis, rhGH initiation, dialysis initiation and transplantation
Main finding
As reported in the abstract
rhGH-treated
+0.7
median · SD
- Median height at rhGH initiation
- −2.0 SDS
- Height gain p value
- P < 0.0001
Observational data: associations, not effects.
Further findings
Height SDS below −2 SDS · at transplantation
- Height change from diagnosis to transplantation in rhGH-untreated
- −0.6 · SD
- Height change from diagnosis to transplantation in rhGH-untreated — Loss of 0.6 SD in untreated
- p = 0.02
Height change from diagnosis to transplantation in rhGH-untreated
- Untreated maintained height in the normal range
rhGH prescribing patterns
- rhGH initiated by nephrologists
- 52%
- rhGH initiated by endocrinologists
- 48%
- Deviations from marketing authorization criteria
- 68%
- Endocrinologists typically prescribed rhGH for children under 2 years; nephrologists for height above −2 SDS
Original publication
Growth and Recombinant Human Growth Hormone Use in Children with Congenital Chronic Kidney Disease: A Multicentric Contemporary Study. Horm Res Paediatr. Published 16 January 2025. doi:10.
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