Clinical Course of Congenital Hypothyroidism With Gland In Situ and Necessity of L-Thyroxine Therapy After Re-evaluation
Authors' conclusion
Monitoring thyroid function in children with CH and GIS is necessary to evaluate the need for substitution and avoid overtreatment. Even if therapy can be suspended, patients need to be monitored because apparently normal thyroid function may decline several months after withdrawal of LT4.
Study context
- Population
- Patients with confirmed primary congenital hypothyroidism with gland in situ after positive neonatal screening, all started on L-thyroxine (LT4), followed at the referral regional center for congenital hypothyroidism (CH) of Pisa55 reassessed at 3 years
- Participants
- 77 patients
- Outcome
- Proportion of patients who can suspend LT4 therapy during follow-up
Methodological detailssingle referral regional centre
- Single referral regional centre
Main finding
As reported in the abstract
Euthyroid at reevaluation after LT4 withdrawal · 3 years of age
Euthyroid among 55 reassessed
18
32.7%
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| LT4 dose before last trial off medicationHigher in permanent CH | P .016 |
LT4 status during subsequent follow-up
- No longer treated
- 49%
- Taking therapy
- 51%
- Adequate follow-up data for 49 patients
Neonatal parameters, no longer treated vs treated
- No differences in neonatal parameters between the 2 groups
Original publication
Clinical Course of Congenital Hypothyroidism With Gland In Situ and Necessity of L-Thyroxine Therapy After Re-evaluation. J Clin Endocrinol Metab. Published 10 July 2024. doi:10.
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