Association Between Systemic Lupus Erythematosus and Primary Hypothyroidism: Evidence from Complementary Genetic Methods
Authors' conclusion
In summary, a bidirectional causal relationship between SLE and primary hypothyroidism was observed with complementary genetic approaches.
Study context
- Population
- Summary statistics from large-scale genome-wide association studies of systemic lupus erythematosus (SLE), primary hypothyroidism and thyroid-stimulating hormone (TSH)
- Comparison
- SLE vs primary hypothyroidism
- Outcome
- Causal association between SLE and primary hypothyroidism
Methodological detailsgenetic correlation, bidirectional Mendelian randomization (MR), colocalization analysis, validation data set
- Genetic correlation
- Bidirectional MR
- Colocalization analysis
- Validation data set
Performance
As reported in the abstract
Genetic correlation between SLE and primary hypothyroidism (LD score regression), P = 6.00 × 10-4
0.2488
OR of SLE on primary hypothyroidism (IVW MR), 95% CI 1.013-1.061, P = 2.00 × 10-3
1.037
OR of primary hypothyroidism on SLE (IVW MR), 95% CI 1.217-1.520, P < 0.001
1.359
Further findings
SLE and TSH
- OR of SLE on TSH, 95% CI 1.001-1.013, P = 0.032
- 1.007
- TSH not causally associated with SLE, P = 0.152
Sensitivity, colocalization and validation
- Similar results with different MR methods
- Colocalization suggested shared causal variants between SLE and primary hypothyroidism
- Validation analysis indicated bidirectional causal relationship and shared loci
Original publication
Association Between Systemic Lupus Erythematosus and Primary Hypothyroidism: Evidence from Complementary Genetic Methods. J Clin Endocrinol Metab. Published 20 October 2022. doi:10.
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