Maternal Thyroid Dysfunction and Neuropsychological Development in Children
Authors' conclusion
Maternal overt hypothyroidism, subclinical hypothyroidism/hyperthyroidism, and hypothyroxinemia during early pregnancy were associated with weakened neuropsychological development in infancy, and some effects may be sex specific.
Study context
- Population
- Mothers and their children from the Shanghai Birth Cohort; thyroid hormones assessed at about 12 gestational weeks
- Participants
- 1,903 mother-child pairs
- Exposure
- Maternal thyroid dysfunction categories vs euthyroid
- Outcome
- Offspring neuropsychological development: Ages and Stages Questionnaire at 6 months and Bayley Scales at 24 months
- Follow-up
- 6 and 24 months
Methodological detailsbirth cohort
- Birth cohort
Main finding
As reported in the abstract
Neuropsychological development scores vs children of euthyroid mothers
- Overt hypothyroidism: lower personal-social domain score, girls, 6 months
- 7.0 points (95% CI, 1.7-12.4)
- Overt hypothyroidism: lower motor domain score, boys, 24 months
- 7.3 points (95% CI, 2.0-12.6)
- Overt hypothyroidism: lower social-emotional score, boys, 24 months
- 7.7 points (95% CI, 1.1-14.2)
- Subclinical hypothyroidism: poorer social-emotional domain, boys, 6 months
- 6.5 points (95% CI, 1.0-12.1)
- Subclinical hypothyroidism: poorer adaptive behavior domain, boys, 24 months
- 7.4 points (95% CI, 0.1-14.8)
- Hypothyroxinemia: lower motor score, boys, 24 months
- 9.3 points (95% CI, 3.5-15.1)
- Subclinical hyperthyroidism: lower language score, girls, 24 months
- 6.9 points (95% CI, 0.1-13.7)
Observational data: associations, not effects.
Original publication
Maternal Thyroid Dysfunction and Neuropsychological Development in Children. J Clin Endocrinol Metab. Published 5 October 2022. doi:10.
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