Novel Causal Plasma Proteins for Hypothyroidism: A Large-scale Plasma Proteome Mendelian Randomization Analysis
Authors' conclusion
Thirteen various proteins were identified and validated to be associated with hypothyroidism using univariable MR. We reinforced and expanded the effect of IFN on hypothyroidism. Several proteins identified in this study could explain part of the association between the coagulation system and hypothyroidism. Our study broadens the causal proteins for hypothyroidism and provides the relationships between plasma proteins and hypothyroidism. The proteins identified in this study can be used as early screening biomarkers for hypothyroidism.
Study context
- Outcome
- Causal plasma proteins for hypothyroidism
Methodological detailslarge-scale plasma proteome, pQTLs for 2297 plasma proteins, discovery and validation cohorts, colocalization and enrichment analysis
- Large-scale plasma proteome
- pQTLs for 2297 plasma proteins
- Discovery and validation cohorts
- Colocalization and enrichment analysis
Performance
As reported in the abstract
Proteins identified in discovery cohort
31
Proteins validated in validation cohort
13
Risk proteins: ISG15, Fc receptor-like protein 2, TNF ligand superfamily member 14, Rab-2A, FcRL3, thrombomodulin, IFN-lambda-1, platelet glycoprotein Ib alpha chain, IL-7RA
9
Further findings
Colocalization of POGLUT1 with expression QTLs
- Whole blood PP4
- 0.978
- Thyroid PP4
- 0.978
Colocalization of IFN-lambda-1 trans-pQTLs with hypothyroidism
- rs2111485 PP4
- 0.998
- rs35103715 PP4
- 0.998
Original publication
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