Subclinical Thyroid Dysfunction and Mortality in an Older, Community‐Dwelling Population—Results of the PolSenior Study
Main finding · Overall mortality, multivariate modelResult — go to the resultHazard ratio 1.43 95% CI 0.98–2.07Authors' conclusion
Our study showed that women with subclinical hyperthyroidism had a higher mortality rate. At the same time, men with treated hypothyroidism had improved survival compared to those in the euthyroid group among participants aged 65 years and older during a 5-year follow-up period. Subclinical hypothyroidism did not influence the survival rates.
Study context
- Population
- Adults aged 65 years and older, PolSenior study407 with thyroid disorders
- Participants
- 305 / 102 / 2,776
- Exposure
- Treated and untreated subclinical thyroid dysfunction vs euthyroid
- Hypothyroidismn = 305
- Hyperthyroidismn = 102
- Euthyroidn = 2,776reference
- Outcome
- Overall mortality
- Follow-up
- 5 years
Methodological detailscommunity-dwelling, Cox proportional hazard regression, Kaplan-Meier estimates stratified by sex and hypo-/hyperthyroidism status
- Community-dwelling
- Cox proportional hazard regression
- Kaplan-Meier estimates stratified by sex and hypo-/hyperthyroidism status
Main finding
Overall mortality, multivariate model
Hazard ratio
1.43
95% CI 0.98–2.07
P = 0.06
Subclinical hyperthyroidism (women)vs Euthyroid
HR 1.43 (95% CI 0.98–2.07); P = 0.06
As reported in the abstract
Observational data: associations, not effects.
Original publication
Subclinical Thyroid Dysfunction and Mortality in an Older, Community‐Dwelling Population—Results of the PolSenior Study. Clin Endocrinol (Oxf). Published 24 February 2025. doi:10.
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