Association of Thyroid Dysfunction in Individuals ≥ 65 Years of Age With Subclinical Cardiac Abnormalities
Authors' conclusion
In this free-living elderly cohort, subclinical and overt hypothyroidism were associated with abnormalities of blood biomarkers consistent with diastolic overload and myocardial necrosis respectively, whereas subclinical hyperthyroidism tended to be associated with myocardial fibrosis and decreased left atrial strain. Our findings could represent stage B heart failure and illuminate distinct aspects of the pathobiology of heart disease related to thyroid gland dysfunction with potential clinical implications.
Study context
- Population
- Older individuals in the Cardiovascular Health Study, a community-based cohort recruited from 4 urban areas in the United States
- Participants
- 3,163 individuals
- Exposure
- Thyroid dysfunction categories vs euthyroid
- Euthyroidn = 2,477reference
- Subclinical hypothyroidism (SCH)n = 465
- Overt hypothyroidism (OH)n = 47
- endo-SCTn = 45
- exo-SCTn = 129
- Outcome
- Cardiac biomarkers and left heart echocardiographic strain
Methodological detailscommunity-based cohort, Cardiovascular Health Study
- Community-based cohort
- Cardiovascular Health Study
Main finding
As reported in the abstract
Beta (NT-proBNP)
0.17
P = 0.004
SCH · higher NT-proBNP with SCH
Beta (hs-cTnT)
0.29
P = 0.005
OH · higher hs-cTnT with OH
Observational data: associations, not effects.
Original publication
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