Comparative Analysis of Taxonomic and Functional Gut Microbiota Profiles in Relation to Seroconversion of Thyroid Peroxidase Antibodies in Euthyroid Participants
Authors' conclusion
These findings suggest that there is no robust difference in gut microbiome between individuals with or without TPOAb in terms of alpha and beta-diversity. Nonetheless, several taxa were identified with nominal significance related to TPOAb presence.
Study context
- Population
- Euthyroid participants from the multiethnic (European Dutch, Moroccan, and Turkish) HEalthy Life In an Urban Setting (HELIUS) cohort
- Participants
- 159 vs 1,309
- Exposure
- Euthyroid thyroid peroxidase antibodies (TPOAb)-seropositive vs seronegative participants
- TPOAb+n = 159
- TPOAb−n = 1,309reference
- Outcome
- Taxonomic and functional signatures of the intestinal microbiota associated with serum TPOAb
Methodological detailsmultiethnic cohort (HELIUS), 16S rRNA sequencing
- Multiethnic cohort (HELIUS)
- 16S rRNA sequencing
Main finding
As reported in the abstract
Microbiome variance accounted for by TPOAb status (p = 0.545)
0.07%
Taxa nominally associated with TPOAb status
138
Taxa with consistent nominal significance across three additional differential abundance (DA) methods, with associations in various functional pathways
13
Observational data: associations, not effects.
Further findings
Serum thyroid markers across the three ethnic groups
- No significant disparities in serum thyroid markers among ethnic groups (p > 0.05 for TSH, FT4 and TPOAb); ethnicity-specific reference intervals not required
Original publication
Comparative Analysis of Taxonomic and Functional Gut Microbiota Profiles in Relation to Seroconversion of Thyroid Peroxidase Antibodies in Euthyroid Participants. Thyroid. Published 3 January 2024. doi:10.
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