Potential Determinants of Thyroid Peroxidase Antibodies and Mortality Risk: Results From the ELSA-Brasil Study
Authors' conclusion
Sociodemographic and lifestyle-related factors were determinants of multiple TPOAb categories. TPOAb levels were associated with mortality risk; however, the low mortality rate in this sample might have compromised this finding. We suggest further studies to explore the clinical importance of detectable TPOAb levels, not only its positivity, as a potential marker of inflammation.
Study context
- Population
- Participants of the ELSA-Brasil Study
- Participants
- 13,187 participants
- Exposure
- TPOAb levels, detectability, positivity and persistent positivity in relation to determinants and mortality
- Outcome
- Determinants of TPOAb levels; association of TPOAb titers with all- and specific-cause mortality
Methodological detailsbaseline and longitudinal data
- Baseline and longitudinal data
Main finding
As reported in the abstract
- Determinants of TPOAb detectability and positivity: younger age, higher BMI, female sex, former and current smoking
- Black, mixed and other self-reported races, intermediate and higher education, and heavy drinking were determinants of detectable and positive TPOAb levels
- Female sex, White race and former smoking were determinants of persistent TPOAb positivity at 2 visits; only female sex maintained its association at 3 visits
- After multivariate adjustment, higher TPOAb levels associated with higher risk of cancer-related mortality among men
- After multivariate adjustment, TPOAb detectability associated with mortality by other causes among women
- Logistic regressions; Cox proportional hazards and Fine-Gray subdistribution hazard regression
Observational data: associations, not effects.
Original publication
Potential Determinants of Thyroid Peroxidase Antibodies and Mortality Risk: Results From the ELSA-Brasil Study. J Clin Endocrinol Metab. Published 12 September 2023. doi:10.
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