Thyroid antibody status, thyroid function, and the risk of coronary heart disease and stroke: an individual participant data analysis from 14 cohorts
Authors' conclusion
Positive TPOAb status was not associated with increased risk of CHD or stroke. These findings do not support the use of TPOAb testing for cardiovascular risk assessment in the overall population or among individuals with subclinical hypothyroidism.
Study context
- Population
- Adults from 14 cohort studies (Thyroid Studies Collaboration and systematic searches through November 2024); median age 55 years, 56.7% women; 11.9% thyroid peroxidase antibodies (TPOAb)-positive, 5.4% SCH
- Participants
- 100,250 adults14 cohort studies
- Comparison
- TPOAb-positive vs TPOAb-negative
- Outcome
- Coronary heart disease (CHD) events, CHD mortality, stroke events and stroke mortality
Methodological details2-stage individual participant data analysis, Cox proportional hazards models adjusted for age, sex and thyroid-stimulating hormone (TSH), random-effects meta-analysis
- 2-stage individual participant data analysis
- Cox proportional hazards models adjusted for age, sex and TSH
- Random-effects meta-analysis
Pooled result
As reported in the abstract
CVD outcomes, overall population
TPOAb-positive vs TPOAb-negativeHazard ratio (95% CI)
CHD events
1.00(0.90–1.11)
CHD mortality
0.95(0.78–1.16)
Stroke events
0.98(0.87–1.11)
Stroke mortality
1.06(0.81–1.40)
Further pooled results
Cardiovascular disease (CVD) outcomes in SCH subgroup
- In SCH, positive TPOAb was not associated with increased risk for any CVD outcome
Original publication
Thyroid antibody status, thyroid function, and the risk of coronary heart disease and stroke: an individual participant data analysis from 14 cohorts. Eur J Endocrinol. Published 24 October 2025. doi:10.
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