Sex-Specific Associations between Maternal Thyroid Peroxidase Antibodies and Cognitive Development in Preschool Children: A Prospective Cohort Study
Authors' conclusion
Positive maternal TPOAb levels during pregnancy may be associated with poorer cognitive development in preschool children.
Study context
- Population
- Mother-child pairs from the Ma'anshan Birth Cohort (MABC) Study; mothers' mean [SD] age 26.7 [3.6] years
- Participants
- 1,849 mother-child pairs
- Exposure
- Maternal thyroid peroxidase antibody (TPOAb) positivity vs negativity during pregnancy
- Outcome
- Cognitive development of preschool children (WPPSI-IV, Chinese version), by sex
- Follow-up
- Preschool age
Methodological detailsbirth cohort, sex-stratified analysis
- Birth cohort
- Sex-stratified analysis
Main finding
As reported in the abstract
Below-average cognitive indices by maternal TPOAb positivity, by sex
TPOAb-positive vs TPOAb-negativeOdds ratio (95% CI)
First trimester; below-average processing speed index; girls
2.07(1.06–4.01)
First trimester; below-average FSIQ; boys
2.36(1.10–5.05)
Third trimester; below-average WMI; girls
2.51(1.02–6.20)
Observational data: associations, not effects.
Further findings
Cognitive scores in girls with increasing maternal lgTPOAb during pregnancy
- Working memory index (WMI) β
- −3.17 (95% CI: −5.82 to −0.52)
- Fluid reasoning index (FRI) β
- −4.49 (95% CI: −7.18 to −1.80)
- Full-scale intelligence quotient (FSIQ) score β
- −2.43 (95% CI: −4.77 to −0.08)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Sex-Specific Associations between Maternal Thyroid Peroxidase Antibodies and Cognitive Development in Preschool Children: A Prospective Cohort Study. Thyroid. Published 7 June 2024. doi:10.
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