Sex-specific effect of maternal thyroid peroxidase antibody exposure during pregnancy on 5- to 6-year-old children's cardiometabolic risk score: the Ma'anshan birth cohort study
Authors' conclusion
The first trimester of pregnancy is a critical period for maternal TPOAb exposure to affect CMR in children, with some sex specificity, mainly to the detriment of boys.
Study context
- Population
- Mother-child pairs from the Ma'anshan Birth Cohort (MABC); maternal mean (SD) age 26.6 (3.6) years; children's cardiometabolic risk (CMR) assessed at age 5–6 years
- Participants
- 2,129 mother-child pairs
- Exposure
- High vs low maternal thyroid peroxidase antibody (TPOAb) trajectory during pregnancy
- Outcome
- Children's CMR score (serum glycolipids, blood pressure, waist circumference)
- Follow-up
- Age 5-6 years
Methodological detailsSerum TPOAb measured retrospectively by electrochemiluminescence immunoassay; trajectories fitted by growth mixture modelling; linear and logistic regression
- Serum TPOAb measured retrospectively by electrochemiluminescence immunoassay; trajectories fitted by growth mixture modelling; linear and logistic regression
Main finding
As reported in the abstract
High TPOAb trajectory vs Low TPOAb trajectoryEstimate (95% CI)
High CMR
OR 3.40(1.30–8.90)
Hyperglycemia
OR 5.20(2.20–12.28)
Insulin resistance
aOR 2.12(1.10–4.07)
Hypertriglyceridemia
OR 2.55(1.06–6.14)
Observational data: associations, not effects.
Further findings
First-trimester maternal TPOAb exposure
- Increased children's overall CMR, glucose, HOMA-IR, TG, boys' overall CMR, boys' glucose and girls' glucose
- Associated with lower high-density lipoprotein cholesterol (HDL-C) in boys
Second-trimester maternal TPOAb exposure
- Positively associated with children's TG level
Original publication
Sex-specific effect of maternal thyroid peroxidase antibody exposure during pregnancy on 5- to 6-year-old children's cardiometabolic risk score: the Ma'anshan birth cohort study. Eur J Endocrinol. Published 22 August 2024. doi:10.
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