Association of maternal thyroid peroxidase antibody exposure with children’s emotional and behavioral problems
Authors' conclusion
Maternal TPOAb positivity during pregnancy may be associated with emotional and behavioral problems in preschool-aged children.
Study context
- Population
- Mother-infant pairs from the Ma'anshan birth cohort, China; children's emotional and behavioral problems assessed at 4 years with the strengths and difficulties questionnaire
- Participants
- 2,464 mother-infant pairs
- Exposure
- Maternal thyroid peroxidase antibody (TPOAb) positivity vs negativity during pregnancy
- Outcome
- Emotional and behavioral problems (strengths and difficulties questionnaire)
- Follow-up
- 4 years of age
Methodological detailsMa'anshan birth cohort, adjusted for potential confounders, TPOAb and FT4 measured retrospectively by electrochemiluminescence immunoassay (ECLIA) in repeated maternal blood samples
- Ma'anshan birth cohort
- Adjusted for potential confounders
- TPOAb and FT4 measured retrospectively by ECLIA in repeated maternal blood samples
Main finding
As reported in the abstract
Emotional and behavioral problems by trimester of TPOAb exposure and child sex · 4 years
TPOAb positive vs TPOAb negativeOdds ratio (95% CI)
Conduct problems in girls; third-trimester TPOAb positivity; adjusted
2.190(1.137–4.219)
Prosocial behavior in boys; first-trimester TPOAb positivity; adjusted
0.451(0.237–0.861)
Observational data: associations, not effects.
Original publication
Association of maternal thyroid peroxidase antibody exposure with children’s emotional and behavioral problems. Eur Thyroid J. Published 8 April 2025. doi:10.
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