Thyroid function test abnormalities‐isolated TPOAb+, SCH and hypothyroxinemia and preschool children's neurodevelopment
Authors' conclusion
Thyroid function test abnormalities before 20 gestational weeks may be associated with children's neurodevelopment at 3-6 years of age.
Study context
- Population
- Mother-child pairs; children aged 3–6 years assessed with parental BRIEF-P and SDQ; maternal TSH, FT4 and TPOAb measured by chemiluminescence immunoassay
- Participants
- 2,243 mother-child pairs
- Exposure
- Maternal thyroid function test abnormalities (isolated TPOAb+, isolated SCH, isolated hypothyroxinemia) before 20 gestational weeks vs none
- Outcome
- Children's cognitive, emotional and behavioural development (abnormalities on BRIEF-P and SDQ)
- Follow-up
- 3-6 years of age
Methodological detailsretrospective evaluation of maternal thyroid function, Poisson regression adjusted for potential confounders
- Retrospective evaluation of maternal thyroid function
- Poisson regression adjusted for potential confounders
Main finding
As reported in the abstract
Abnormalities in preschoolers' neurodevelopment · 3-6 years
Odds ratio (95% CI)
Isolated TPOAb+peer problems
1.90(1.26–287)
Isolated SCHinhibition
2.73(1.37–5.41)
Isolated SCHworking memory
1.67(1.04–2.70)
Isolated SCHconduct problems
1.80(1.05–3.09)
Isolated SCHhyperactivity
1.94(1.08–3.49)
Isolated SCHtotal difficulties
1.94(1.13–3.34)
Isolated hypothyroxinemiapeer problems
2.71(1.17–6.27)
Observational data: associations, not effects.
Original publication
Thyroid function test abnormalities‐isolated TPOAb+, SCH and hypothyroxinemia and preschool children's neurodevelopment. Clin Endocrinol (Oxf). Published 25 August 2023. doi:10.
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