Increased Risk of Thyroid Eye Disease Following Covid-19 Vaccination
An erratum to this article was published (J Clin Endocrinol Metab, 17 May 2024 ↗)
Authors' conclusion
The risk of TED was significantly increased after Covid-19 vaccination, especially in people below 50 years of age. Possible mechanisms include spike protein interaction with the angiotensin-converting enzyme II receptor, cross-reactivity with thyroid self-proteins, and immune reactions induced by adjuvants. We suggest monitoring of individuals undergoing Covid-19 vaccination, especially if young and at risk for autoimmunity.
Study context
- Population
- Consecutive patients with newly developed or reactivated thyroid eye disease (TED) between January 1, 2021, and August 31, 2022, at a tertiary referral center for TED81 vaccinated · or reactivated 6
- Participants
- 98 patients
- Exposure
- Exposed vs unexposed periods
- Outcome
- Risk of TED following Covid-19 vaccination (IRR, exposed vs unexposed)
- Follow-up
- 1 to 28 days after vaccination
Methodological detailstertiary referral centre, consecutive patients
- Tertiary referral centre
- Consecutive patients
Main finding
TED
Incidence rate ratio
3.24
95% CI 2.01–5.20
Events by group
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | IRR (95% CI) | |
|---|---|---|
| TED in patients below 50 years of age | 4.70 (2.39–9.23) | |
| 0.10.31310Incidence rate ratio (log scale) |
Effect modification by sex, smoking and RAI
- Sex, smoking and RAI treatment did not modify the association between TED and vaccination
TED risk by number of doses and time since vaccination
- TED risk progressively decreased over time following vaccination
- P for trend = 0.03
- TED risk unrelated to number of vaccine doses
Original publication
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